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MESENCHYMAL STEM CELLS CULTURE SKIN

Researchers at the Tufts University Center for Cellular Agriculture (TUCCA) have made strides toward this objective by developing immortalized bovine muscle stem cells (iBSCs). The production of muscle cells from sources such as chicken, fish, cows, and more will need to increase to the point where millions of metric tons are yielded annually. Credit: Andrew Stout, Tufts University Minimizing the necessity for animal biopsies, stem cells offer a potentially endless source for cultured meat.įor cellular agriculture-a technique that grows meat in bioreactors-to successfully feed millions, numerous technological hurdles must be conquered. 2017 358:1267.Differentiated immortalized bovine stem cells with fully expressed muscle proteins (blue = nuclei magenta = myogenin green = myosin).

MESENCHYMAL STEM CELLS CULTURE SKIN

Skin stem cells regenerate a human epidermis. Epidermal stem cells in wound healing and their clinical applications.

Yang R., Liu F., Wang J., Chen X., Xie J., Xiong K. Clinical Potential and Current Progress of Dental Pulp Stem Cells for Various Systemic Diseases in Regenerative Medicine: A Concise Review. Yamada Y., Nakamura-Yamada S., Kusano K., Baba S. Identification of the human skeletal stem cell. doi: 10.3906/biy-1802-52.Ĭhan C.K.F., Gulati G.S., Sinha R., Tompkins J.V., Lopez M., Carter A.C., Ransom R.C., Reinisch A., Wearda T., Murphy M. Comparative study of mesenchymal stem cells from rat bone marrow and adipose tissue. This review highlights and updates on the progress of production, as well as provides further challenges in the studies of BMSCs, for the approval of BMSCs widely in clinical application.īone marrow mesenchymal stem cells clinical application culture isolation stem cell therapy storage. Based on the International Society for Cellular Therapy guidelines, the characterization, isolation, cultivation, differentiation, and applications can be optimized and standardized, which are compliant with good manufacturing practice requirements to produce clinical-grade preparation of BMSCs. The number of clinical trials in phase I/II is accelerating however, they are limited in the size of subjects, regulations, and standards for the preparation and transportation and administration of BMSCs, leading to inconsistency in the input and outcome of the therapy. In-vitro and in-vivo studies have supported the understanding mechanisms, safety, and efficacy of BMSCs therapy in clinical applications.

11 Institute of Cancer Research, Oslo University Hospital, 0310 Oslo, Norway.īone marrow mesenchymal stem/stromal cells (BMSCs), which are known as multipotent cells, are widely used in the treatment of various diseases via their self-renewable, differentiation, and immunomodulatory properties.

10 Institute for Research and Development, Duy Tan University, Danang 550000, Vietnam.

9 AI Lab, Faculty of Information Technology, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam.

8 Vietnam Military Medical University, Hanoi 100000, Vietnam.

7 Center for Anesthesia and Surgical Intensive Care, Viet Duc Hospital, Hanoi 100000, Vietnam.

6 Department of Surgery, Hanoi Medical University, Hanoi 100000, Vietnam.

5 Department of Anatomy, University of Medicine Pham Ngoc Thach, Ho Chi Minh City 700000, Vietnam.

4 Institute of Orthopaedics and Trauma Surgery, Viet Duc Hospital, Hanoi 100000, Vietnam.

3 Department of Animal Science, College of Agriculture and Life Science, Chonnam National University, Gwangju 61186, Korea.

2 School of Odonto Stomatology, Hanoi Medical University, Hanoi 100000, Vietnam.

1 Faculty of Biology, Hanoi National University of Education, Hanoi 100000, Vietnam.